High dose intravenous methylprednisolone or high dose intravenous gammaglobulin for autoimmune thrombocytopenia

High-dose intravenous gammaglobulin therapy for acquired von Willebrand disease.

Patients with acquired von Willebrand disease may present with severe bleeding, which is usually difficult to manage. Adequate haemostasis in acquired von Willebrand disease may be achieved with the infusion of factor VIII/von Willebrand factor concentrates or with the administration of desmopressin. We report a case of acquired von Willebrand disease with severe postoperative bleeding, respond...

High-dose intravenous gammaglobulin in alloimmunized platelet transfusion recipients.

High-dose intravenous gammaglobulin (polyvalent immunoglobulin G) has been shown to be of benefit in some patients with immune thrombocytopenic purpura (ITP), possibly by producing reticuloendothelial system blockade. We studied this approach in patients refractory to random donor platelet transfusion using an IV IgG preparation manufactured by the Swiss Red Cross. Eleven adult patients with ac...

High dose intravenous gammaglobulin in chronic systemic juvenile arthritis.

High-dose intravenous methylprednisolone for constitutional pure red cell aplasia.

I read with interest the recent article by Lenarsky et al’ about bone marrow transplantation (BMT) for Diamond-Blackfan syndrome. I reported a case of constitutional pure red cell aplasia (CPRCA) refractory to conventional prednisone (2 mg/kg) administration treated with high-dose intravenous (IV) methylprednisolone (HIVMP) (30 mg/kg for 3 days, 20 mg/kg for 4 days, then subsequently 10, 5, and...

A prospective study of treatment of acquired (autoimmune) factor VIII inhibitors with high-dose intravenous gammaglobulin.

A decrease in inhibitor titer has been reported in some patients with acquired factor VIII inhibitors treated with intravenous gammaglobulin (IGIV). We have conducted a prospective, multicenter study of high-dose IGIV in treatment of this disorder to determine efficacy. Nineteen patients received induction therapy with IGIV, 1,000 mg/kg x 2 consecutive days or 400 mg/kg x 5 consecutive days, fo...